Association of anti-Ro52 autoantibodies with interstitial lung disease in connective tissue diseases

Published on Sep 1, 2021in Annals of the Rheumatic Diseases16.102
· DOI :10.1136/ANNRHEUMDIS-2019-216372
Si Wu1
Estimated H-index: 1
(NU: Nanjing University),
Xiaojun Tang11
Estimated H-index: 11
(NU: Nanjing University)
+ 2 AuthorsXuebing Feng28
Estimated H-index: 28
(NU: Nanjing University)
Sources
Abstract
We read with great interest the article by Sabbagh et al demonstrating that anti-Ro52 autoantibodies were connected with the development of interstitial lung disease (ILD) in patients with juvenile myositis.1 Anti-Ro52 has been found in a variety of connective tissue diseases (CTDs) and drawn considerable attention from rheumatologists in recent years. Besides myositis, these autoantibodies have also been reported to be related to ILD in several other CTDs, but with great discrepancy across the studies.2 In addition, it remains unclear how the incidence of ILD differs in the presence of anti-Ro52 alone or in combination with anti-Ro60 (Sjogren's syndrome related antigen A), one of the most associated antibodies that may determine anti-Ro52 …
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#1Sara Sabbagh (NIH: National Institutes of Health)H-Index: 2
Last. Andrew L. MammenH-Index: 50
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Objectives Anti-Ro52 autoantibodies are associated with more severe interstitial lung disease (ILD) in adult myositis patients with antiaminoacyl transfer (t)RNA synthetase autoantibodies. However, few studies have examined anti-Ro52 autoantibodies in juvenile myositis. The purpose of this study was to define the prevalence and clinical features associated with anti-Ro52 autoantibodies in a large cohort of patients with juvenile myositis. Methods We screened sera from 302 patients with juvenile ...
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#1Jennifer Hannah ('KCL': King's College London)H-Index: 2
#2David D'Cruz (Guy's and St Thomas' NHS Foundation Trust)H-Index: 61
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by the production of pathogenic autoantibodies and immune complexes and is responsible for significant morbidity and mortality through a wide range of clinical manifestations which can affect almost any organ. Pulmonary involvement is prevalent and seen in 50 to 70% of SLE patients and may even be the presenting feature in 4 to 5% of patients. By 10 years postdiagnosis, 12% will have accumulated an element of per...
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#1Ailsa Robbins (Reims University)H-Index: 5
#3Ségolène Toquet (Reims University)H-Index: 4
Last. Delphine Giusti (URCA: University of Reims Champagne-Ardenne)H-Index: 6
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Anti-SS-A antibodies are often sought for in autoimmune diseases diagnosis. Two different target proteins have actually been identified: Ro52 and Ro60. Clinical and immunological associations seem different depending on anti-Ro52 or anti-Ro60 antibodies presence. However, due to a heterogeneous presentation in the literature, some immunology laboratories in France have stopped providing anti-Ro52 antibody findings. We report here a new hospital study designed to determine the diagnostic utility ...
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#1Athanasios Gkoutzourelas (RMIT: RMIT University)H-Index: 4
#2Christos Liaskos (RMIT: RMIT University)H-Index: 24
Last. Lazaros I. Sakkas (RMIT: RMIT University)H-Index: 30
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Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with Sjogren’s syndrome (SjS) and systemic lupus erythematosus (SLE). Comprehensive epitope mapping in systemic sclerosis (SSc), where anti-Ro52 antibodies are also frequently detected, has not been performed. The aim of the present study was to fully characterize Ro52 epitopes in anti-Ro52-positive SSc using Ro52 fragments spanning the full antigen. Further analysis was made according to anti-Ro60 status. Epi...
8 CitationsSource
#1Sai H K Murng (NHS Greater Glasgow and Clyde)H-Index: 1
#2Moira Thomas (NHS Greater Glasgow and Clyde)H-Index: 1
Aims Autoantibodies targeting Ro52 and Ro60 antigens are historically reported as anti SSA/Ro. In general anti SSA/Ro results are either anti Ro52+Ro60+ or anti Ro52−Ro60+ antibodies. Anti Ro52 without anti Ro60 (Ro52+ Ro60−) antibodies are often not reported routinely. This study intends to review the potential significance of these autoantibodies in the management of connective tissue diseases. Method A retrospective survey of Ro52+Ro60− was carried out as part of the service evaluation of ext...
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#1Adrian Y.S. Lee (UTAS: University of Tasmania)H-Index: 10
Anti-Ro52/tripartite motif-containing 21 (TRIM21) is a ubiquitous antibody found in a number of systemic autoimmune conditions including Sjogren’s syndrome, systemic lupus erythematosus and systemic sclerosis, appearing in about half of these patients. Once coupled with its closely related antibody, anti-Ro60 as the anti-SSA antibody, anti-Ro52 is emerging as a unique antibody with direct pathogenic disease involvement and distinct clinical properties. As a result, recent attention has turned to...
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Cited By4
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#1Chi Shao (Peking Union Medical College Hospital)H-Index: 2
#2Yuxin Sun (Peking Union Medical College Hospital)H-Index: 2
Last. Zuojun Xu (Peking Union Medical College Hospital)H-Index: 8
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Objectives null Anti-Ro-52 antibody positivity might be associated with the presence of interstitial lung disease (ILD) among patients with autoimmune features. However, the clinical significance of isolated anti-Ro-52 positivity (i.e., the presence of anti-Ro52 antibodies but the absence of anti-Ro60 antibodies; anti-Ro52+-Ro60-) in patients with ILD is not clear. null Methods null This is a prospective and observational study of Chinese ILD patients with isolated anti-Ro-52 positivity. Accordi...
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#2Thomas Moulinet (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last. Roland JaussaudH-Index: 14
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Objectives Clinical significance of anti-Ro52 antibodies in connective tissue diseases (CTD) is controversial. Anti-Ro52 antibodies might be associated with a more severe CTD phenotype, especially interstitial lung disease (ILD). The aims of this study were to evaluate ILD prevalence and severity, the prevalence of micro- or macroangiopathy and CTD-associated cancers in CTD with anti-Ro52 antibodies. Methods CTD patients with anti-Ro52 antibody screening by immunoblot at diagnosis were enrolled....
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#1Si Wu (NU: Nanjing University)H-Index: 1
#2Xiaojun Tang (NU: Nanjing University)H-Index: 11
Last. Xuebing Feng (NU: Nanjing University)H-Index: 28
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INTRODUCTIONS To analyse the clinical significance of anti-Ro52 autoantibodies that target TRIM21 protein and occur in a variety of connective tissue diseases (CTD), 4782 cases with blood tested positive for anti-Ro52 antibodies between January 2016 and September 2017 in Drum Tower Hospital were enrolled. METHODS Anti-Ro52 and anti-Ro60 were measured using the immunoblotting method together with antibodies against other extractable nuclear antigens at the time of the patient's first visit. RESUL...
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Antisynthetase syndrome (ASSD) is a rare multisystemic connective tissue disease affecting the skin, joints, muscles, and lungs, characterized by anti-aminoacyl transfer-RNA-synthetases (anti-tRNA) autoantibodies production, being anti-Jo1 the most frequent. We included one-hundred twenty-one ASSD patients and 340 healthy subjects (HS), and also, we divided the case group into anti-Jo1 and non-anti-Jo1. Two single nucleotide polymorphisms (SNPs) in the IL17A gene were evaluated. Anti-Jo1 was the...
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