Association of anti-Ro52 autoantibodies with interstitial lung disease in connective tissue diseases

Published on Sep 1, 2021in Annals of the Rheumatic Diseases16.102
· DOI :10.1136/ANNRHEUMDIS-2019-216372
Si Wu1
Estimated H-index: 1
(NU: Nanjing University),
Xiaojun Tang11
Estimated H-index: 11
(NU: Nanjing University)
+ 2 AuthorsXuebing Feng28
Estimated H-index: 28
(NU: Nanjing University)
We read with great interest the article by Sabbagh et al demonstrating that anti-Ro52 autoantibodies were connected with the development of interstitial lung disease (ILD) in patients with juvenile myositis.1 Anti-Ro52 has been found in a variety of connective tissue diseases (CTDs) and drawn considerable attention from rheumatologists in recent years. Besides myositis, these autoantibodies have also been reported to be related to ILD in several other CTDs, but with great discrepancy across the studies.2 In addition, it remains unclear how the incidence of ILD differs in the presence of anti-Ro52 alone or in combination with anti-Ro60 (Sjogren's syndrome related antigen A), one of the most associated antibodies that may determine anti-Ro52 …
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Anti-SS-A antibodies are often sought for in autoimmune diseases diagnosis. Two different target proteins have actually been identified: Ro52 and Ro60. Clinical and immunological associations seem different depending on anti-Ro52 or anti-Ro60 antibodies presence. However, due to a heterogeneous presentation in the literature, some immunology laboratories in France have stopped providing anti-Ro52 antibody findings. We report here a new hospital study designed to determine the diagnostic utility ...
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#1Sai H K Murng (NHS Greater Glasgow and Clyde)H-Index: 1
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Cited By4
#1Chi Shao (Peking Union Medical College Hospital)H-Index: 2
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#2Thomas Moulinet (CNRS: Centre national de la recherche scientifique)H-Index: 1
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#1Si Wu (NU: Nanjing University)H-Index: 1
#2Xiaojun Tang (NU: Nanjing University)H-Index: 11
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INTRODUCTIONS To analyse the clinical significance of anti-Ro52 autoantibodies that target TRIM21 protein and occur in a variety of connective tissue diseases (CTD), 4782 cases with blood tested positive for anti-Ro52 antibodies between January 2016 and September 2017 in Drum Tower Hospital were enrolled. METHODS Anti-Ro52 and anti-Ro60 were measured using the immunoblotting method together with antibodies against other extractable nuclear antigens at the time of the patient's first visit. RESUL...
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