RIGHT VENTRICULAR - PULMONARY ARTERIAL UNCOUPLING PREDICTS MORTALITY IN CANDIDATES FOR ADVANCED HEART FAILURE THERAPIES

Advanced therapies for heart failure with reduced ejection fraction (HFrEF) include cardiac transplantation and mechanical circulatory support. For both therapies, right ventricular (RV) dysfunction and/or pulmonary hypertension portend adverse outcomes, particularly when systolic PA pressure (sPAP) ≥50 mmHg. End-systolic elastance (Ees) quantifies load-independent systolic RV performance, which can be related to the effective PA load (Ea) by...