AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Abstract
Protein silencing represents an essential tool in biomedical research. Targeted protein degradation (TPD) strategies exemplified by PROTACs are rapidly emerging as modalities in drug discovery. However, the scope of current TPD techniques is limited because many intracellular materials are not substrates of proteasomal clearance. Here, we described a novel targeted-clearance strategy (autophagy-targeting chimera [AUTAC]) that contains a...
Paper Details
Title
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Published Date
Dec 1, 2019
Journal
Volume
76
Issue
5
Pages
797 - 810.e10
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Notes
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