Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

Volume: 10, Issue: 1
Published: Oct 10, 2019
Abstract
Lipid availability within transmembrane nano-pockets of ion channels is linked with mechanosensation. However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has not been demonstrated. Here we identify nano-pockets on the large conductance mechanosensitive channel MscL, the high-pressure threshold channel. We restrict lipid-chain access to the nano-pockets by mutagenesis and sulfhydryl modification, and...
Paper Details
Title
Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
Published Date
Oct 10, 2019
Volume
10
Issue
1
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.