Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory

The pregnane-X-receptor (PXR) is involved in inflammatory bowel disease (IBD). Patchouli alcohol (PA) has anti-inflammatory effects; however, the effect of PA on IBD pathogenesis remains largely unknown. The aim of the present study was to investigate the anti-inflammatory effect of PA, primarily focused on crosstalk between PA-mediated PXR activation and NF-κB inhibition. We evaluated the anti-inflammatory effect of PA with respect to PXR/NF-κB...