Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation

Volume: 145, Issue: 1, Pages: 199 - 214.e11
Published: Jan 1, 2020
Abstract
Psoriasis is a frequent inflammatory skin disease that is mainly mediated by IL-23, IL-1β, and IL-17 cytokines. Although psoriasis is a hyperproliferative skin disorder, the possible role of amino acid transporters has remained unexplored.We sought to investigate the role of the essential amino acid transporter L-type amino acid transporter (LAT) 1 (SLC7A5) in psoriasis.LAT1 floxed mice were crossed to Cre-expressing mouse strains under the...
Paper Details
Title
Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation
Published Date
Jan 1, 2020
Volume
145
Issue
1
Pages
199 - 214.e11
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