Evidence map of pancreatic surgery: protocol for a living systematic review and meta-analysis.

Published on Sep 1, 2019in BMJ Open2.692
· DOI :10.1136/BMJOPEN-2019-032353
Pascal Probst23
Estimated H-index: 23
(Heidelberg University),
Felix J Hüttner17
Estimated H-index: 17
(Heidelberg University)
+ 8 AuthorsMarkus K. Diener51
Estimated H-index: 51
Sources
Abstract
Introduction Pancreatic surgery is a large and complex field of research. Several evidence gaps exist for specific diseases or surgical procedures. An overview on existing knowledge is needed to plan and prioritise future research. The aim of this project is to create a systematic and living evidence map of pancreatic surgery. Methods and analysis A systematic literature search in MEDLINE (via PubMed), Web of Science and Cochrane Central Register of Controlled Trials will be performed searching for all randomised controlled trials (RCT) and systematic reviews (SR) on pancreatic surgery. RCT and SR will be grouped in research topics. Baseline and outcome data from RCT will be extracted, presented and effect sizes meta-analysed. Data from SR will be used to identify evidence gaps. A freely accessible web-based evidence map in the format of a mind map will be created. The evidence map and meta-analyses will be updated periodically. Dissemination After completion of the project, a permanently updated evidence map of pancreatic surgery will be available to patients, physicians, researchers and funding bodies via www.evidencemap.surgery. Its use will allow clinical decision-making based on primary data and prioritisation of future research endeavours. PROSPERO registration number CRD42019133444.
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References28
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Purpose Social media, especially Twitter®, is becoming increasingly important for medical topics. Systematic analyses of the content of these tweets are rare. To date, no analysis of the reception of antibiotic/non-operative-treated acute appendicitis on Twitter® has been performed.
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#1Pascal Probst (Heidelberg University)H-Index: 23
#2Steffen Zaschke (Heidelberg University)H-Index: 2
Last. Markus K. Diener (Heidelberg University)H-Index: 51
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Rationale Blinding reduces performance and detection bias in randomized controlled trials (RCT). There is evidence that lack of blinding leads to overestimation of treatment effects in pharmacological trials. Since surgical trials use interventions with a physical component, blinding is often complicated. The aim of this study was to analyze, in general and abdominal surgery RCT, the status of blinding, the potential for blinding, and the influence of blinding on outcomes.
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#1Felix J Hüttner (Heidelberg University)H-Index: 17
#2L. Capdeville (Heidelberg University)H-Index: 1
Last. Markus K. Diener (Heidelberg University)H-Index: 51
view all 8 authors...
BACKGROUND: RCTs are considered the reference standard in clinical research. However, surgical RCTs pose specific challenges and therefore numbers have been lower than those for randomized trials of medical interventions. In addition, surgical trials have often been associated with poor methodological quality. The objective of this study was to evaluate the evolution of quantity and quality of RCTs in pancreatic surgery and to identify evidence gaps. METHODS: PubMed, CENTRAL and Web of Science w...
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#1Käthe GoossenH-Index: 3
#2Solveig TenckhoffH-Index: 5
Last. Markus K. Diener (University Hospital Heidelberg)H-Index: 10
view all 7 authors...
Background The aim of the present study was to determine empirically which electronic databases contribute best to a literature search in surgical systematic reviews.
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#1Mark Simmonds (Ebor: University of York)H-Index: 26
#2Georgia Salanti (University of Bern)H-Index: 77
Last. Julian Elliott (Monash University)H-Index: 60
view all 4 authors...
Abstract A living systematic review (LSR) should keep the review current as new research evidence emerges. Any meta-analyses included in the review will also need updating as new material is identified. If the aim of the review is solely to present the best current evidence standard meta-analysis may be sufficient, provided reviewers are aware that results may change at later updates. If the review is used in a decision-making context, more caution may be needed. When using standard meta-analysi...
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#1Elie A. Akl (AUB: American University of Beirut)H-Index: 101
#2Joerg J Meerpohl (University of Freiburg)H-Index: 62
Last. Holger J. SchünemannH-Index: 158
view all 5 authors...
Abstract While it is important for the evidence supporting practice guidelines to be current, that is often not the case. The advent of living systematic reviews has made the concept of “living guidelines” realistic, with the promise to provide timely, up-to-date and high-quality guidance to target users. We define living guidelines as an optimization of the guideline development process to allow updating individual recommendations as soon as new relevant evidence becomes available. A major impl...
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#1Julian Elliott (Monash University)H-Index: 60
#2Anneliese Synnot (La Trobe University)H-Index: 24
Last. James Thomas (UCL: University College London)H-Index: 56
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Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in review currency, accuracy, and utility. We are developing a novel approach to systematic review updating termed "Living systematic review" (LSR): systematic reviews that are continually updated, incorporating relevant new evidence as it becomes available. LSRs may be particularly important in fields where research evidence is emerging rapidly, current evidence is uncertain, and new research may change p...
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#1Claudio BassiH-Index: 111
Last. M.W. Büchler (Heidelberg University)H-Index: 79
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Background In 2005, the International Study Group of Pancreatic Fistula developed a definition and grading of postoperative pancreatic fistula that has been accepted universally. Eleven years later, because postoperative pancreatic fistula remains one of the most relevant and harmful complications of pancreatic operation, the International Study Group of Pancreatic Fistula classification has become the gold standard in defining postoperative pancreatic fistula in clinical practice. The aim of th...
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#1Marc G. Besselink (UvA: University of Amsterdam)H-Index: 88
#2L. Bengt van Rijssen (UvA: University of Amsterdam)H-Index: 10
Last. Dirk J. Gouma (UvA: University of Amsterdam)H-Index: 102
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Background Recent literature suggests that chyle leak may complicate up to 10% of pancreatic resections. Treatment depends on its severity, which may include chylous ascites. No international consensus definition or grading system of chyle leak currently is available. Methods The International Study Group on Pancreatic Surgery, an international panel of pancreatic surgeons working in well-known, high-volume centers, reviewed the literature and worked together to establish a consensus on the defi...
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#1Pascal Probst (Heidelberg University)H-Index: 23
#2Felix J Hüttner (Heidelberg University)H-Index: 17
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 34
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
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#1S. Partelli (Esso)H-Index: 2
#2Francesco Sclafani (European Organisation for Research and Treatment of Cancer)H-Index: 1
Last. Philip Poortmans (European CanCer Organisation)H-Index: 5
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Abstract ECCO Essential Requirements for Quality Cancer Care (ERQCC) are written by experts representing all disciplines involved in cancer care in Europe. They give patients, health professionals, managers and policymakers a guide to essential care throughout the patient journey. Pancreatic cancer is an increasing cause of cancer mortality and has wide variation in treatment and care in Europe. It is a major healthcare burden and has complex diagnosis and treatment challenges. Care must be carr...
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#1Felix J HüttnerH-Index: 17
#2Pascal ProbstH-Index: 23
Last. Markus K. Diener (Heidelberg University)H-Index: 51
view all 3 authors...
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