Adipocytes as Anticancer Drug Delivery Depot
Abstract
Tumor-associated adipocytes promote tumor growth by providing energy and causing chronic inflammation. Here, we have exploited the lipid metabolism to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site. Rumenic acid (RA), as an anticancer fatty acid, and a doxorubicin prodrug (pDox) with a reactive oxygen species (ROS)-cleavable linker, are encapsulated in adipocytes to deliver therapeutics in a...
Paper Details
Title
Adipocytes as Anticancer Drug Delivery Depot
Published Date
Nov 1, 2019
Journal
Volume
1
Issue
5
Pages
1203 - 1214
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Notes
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