Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the pagA Promoter Region
Abstract
Anthrax toxin activator (AtxA) regulates the major virulence genes in Bacillus anthracis . The bacterium produces the anthrax toxins, and understanding the mechanism of toxin production may facilitate the development of therapeutics for B. anthracis infection. Since the discovery of AtxA 25 years ago, the mechanism by which it regulates its targets has largely remained a mystery. Here, we provide evidence that AtxA binds to the promoter region...
Paper Details
Title
Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the pagA Promoter Region
Published Date
Dec 1, 2019
Journal
Volume
201
Issue
23
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