Novel CFHR2-CFHR1 Hybrid in C3 Glomerulopathy Identified by Genomic Structural Variation Analysis

C3 glomerulopathy (C3G) is a complement-mediated rare disease characterized by predominant glomerular C3 fragment deposition along with electron-dense deposits on electron microscopy.S1 Definitive diagnosis may be made by the microscopic evaluation of kidney biopsy samples; however, the causes that evoke complement dysregulation in individual cases have not yet been established. The CFH gene encodes a key regulator of the complement pathway, the...