Diagnostic delay does not influence survival of pancreatic cancer patients

Published on Feb 1, 2020in United European gastroenterology journal3.549
· DOI :10.1177/2050640619879004
Caterina Stornello2
Estimated H-index: 2
,
Livia Archibugi13
Estimated H-index: 13
+ 5 AuthorsGabriele Capurso56
Estimated H-index: 56
Sources
Abstract
BackgroundMost pancreatic ductal adenocarcinoma patients present with advanced disease. Whether it is possible to increase survival by earlier diagnosis is unclear.ObjectiveThe purpose of this stud...
References22
Newest
#1Salvatore Paiella (University of Verona)H-Index: 23
#2Gabriele CapursoH-Index: 56
Last. Alessandro ZerbiH-Index: 57
view all 19 authors...
Surveillance programs on high-risk individuals (HRIs) can detect pre-malignant lesions or early pancreatic cancer (PC). We report the results of the first screening round of the Italian multicenter program supported by the Italian Association for the study of the Pancreas (AISP). The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC. The surveillance program included...
16 CitationsSource
2 CitationsSource
#1Rei Suzuki (Fukushima Medical University)H-Index: 17
#2Tadayuki Takagi (Fukushima Medical University)H-Index: 19
Last. Hiromasa Ohira (Fukushima Medical University)H-Index: 30
view all 10 authors...
: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an aggressive course; therefore, it was hypothesized that waiting times during disease management may serve as a prognostic factor for patients with PDAC. Data for all patients with PDAC who received treatment in Fukushima Medical University Hospital were collected. Median disease-free survival and overall survival time were calculated using the Kaplan-Meier method and utilized as cut-off points to divide the patients into 2 groups: A...
2 CitationsSource
#1Jeyakumar R. Apollos (Dumfries and Galloway Royal Infirmary)H-Index: 2
#2Sharukh Sami (Dumfries and Galloway Royal Infirmary)H-Index: 1
Last. Angus McFadyenH-Index: 31
view all 5 authors...
Abstract Background Pancreatic ductal adenocarcinomas are poor prognostic cancers accounting for 3% of all cancer cases in the UK. They often present late in the course of the disease process with non-specific symptoms, including gastro-intestinal(GI) symptoms. Delays in diagnosis occur when investigations are carried out in a primary care setting for GI symptoms. The aim of this study was to assess delays in pancreatic cancer diagnosis when patients were referred for GI investigations and evalu...
2 CitationsSource
#1Vanessa L.Z. Gordon-Dseagu (NIH: National Institutes of Health)H-Index: 6
#2Susan S. Devesa (NIH: National Institutes of Health)H-Index: 103
Last. Rachael Z. Stolzenberg-Solomon (NIH: National Institutes of Health)H-Index: 16
view all 4 authors...
Background: Annual pancreatic cancer incidence rates have been increasing. We examine pancreatic cancer incidence trends by demographics and histologic type. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) registries were available to assess temporal trends and pancreatic cancer rates from 1974 to 2013. Results: Pancreatic cancer incidence rates declined between the 1970s and 1990s but increased from 1994 to 2013 among White males. Among non-Hispanic White and Hispanic m...
64 CitationsSource
#1Marianna SignorettiH-Index: 13
#2Marco J. Bruno (EUR: Erasmus University Rotterdam)H-Index: 23
Last. Gabriele CapursoH-Index: 56
view all 6 authors...
BackgroundData on surveillance for pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals (HRIs) with “familial pancreatic cancer” (FPC) and specific syndromes are limited and heterogeneo...
18 CitationsSource
#1Livia Archibugi (Sapienza University of Rome)H-Index: 13
#2Matteo Piciucchi (Sapienza University of Rome)H-Index: 12
Last. Gabriele Capurso (Sapienza University of Rome)H-Index: 56
view all 10 authors...
Data on the association between aspirin and statin use and Pancreatic Ductal AdenoCarcinoma (PDAC) risk are conflicting. These drugs are often co-prescribed, but no studies evaluated the potential combined or confounding effect of the two at the same time. We aimed to investigate the association between aspirin and statin exclusive and combined use and PDAC occurrence. Data on environmental factors, family and medical history were screened in a case-control study. PDAC cases were matched to cont...
20 CitationsSource
#1Koji Shindo (Johns Hopkins University)H-Index: 17
#2Jun Yu (Johns Hopkins University)H-Index: 154
Last. Michael Goggins (Johns Hopkins University)H-Index: 118
view all 22 authors...
PurposeDeleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families in which multiple members have had pancreatic cancer.MethodsTo define the prevalence of these germline mutations in patients with apparently sporadic pancreatic cancer, we sequenced 32 genes, including known pancreatic cancer susceptibility genes, in DNA prepared from normal tissue obtained from 854 patients with pancreatic ductal adenocarcinoma, 288 patients with other pancre...
138 CitationsSource
#1Lingling Du (WashU: Washington University in St. Louis)H-Index: 7
#2Andrea Wang-Gillam (WashU: Washington University in St. Louis)H-Index: 32
Abstract Pancreatic cancer (PDAC) is an aggressive tumor type associated with development of micrometastasis at an early stage. In attempt to eradicate disseminated disease, neoadjuvant therapy has been explored in patients with resectable and borderline resectable PDAC. In large retrospective studies, neoadjuvant therapy was associated with better survival compared with upfront surgery. Previously, trials more commonly used radiotherapy (RT) with small doses of chemotherapy as radiosensitizers....
14 CitationsSource
#1Manfred P. LutzH-Index: 33
#2John Zalcberg (Monash University)H-Index: 71
Last. Florian OttoH-Index: 7
view all 23 authors...
Abstract The primary treatment of pancreatic cancer was the topic of the 3rd St. Gallen Conference 2016. A multidisciplinary panel reviewed the current evidence and discussed controversial issues in a moderated consensus session. Here we report on the key expert recommendations. It was generally accepted that radical surgical resection followed by adjuvant chemotherapy offers the only evidence-based treatment with a chance for cure. Initial staging should classify localised tumours as resectable...
31 CitationsSource
Cited By5
Newest
#1Yue Zhang (Anhui University of Science and Technology)
#2Jinlian Chen (Anhui University of Science and Technology)
Last. Xingxing Zhang (Anhui University of Science and Technology)H-Index: 2
view all 8 authors...
Recent studies have reported that the expression levels of far upstream element‑binding protein 1 (FUBP1) were upregulated and served a crucial role in several types of cancer. However, the underlying molecular mechanisms and clinical significance of FUBP1 in pancreatic adenocarcinoma (PAAD) remain unclear. The present study aimed to determine the expression levels of FUBP1 in patients with PAAD and subsequently investigated the biological functions and mechanisms of FUBP1 using in vitro assays....
Source
#1Gabriele Capurso (UniSR: Vita-Salute San Raffaele University)H-Index: 56
#2Salvatore Paiella (University of Verona)H-Index: 23
Last. Massimo FalconiH-Index: 105
view all 8 authors...
Abstract Pancreatic cancer is one of the main causes of cancer-related death worldwide, with a survival rate around 9%. In Italy 13,500 new cases of pancreatic cancer occurred in 2019. It is estimated that at least 5% have a hereditary background. Surveillance is advisable for healthy individuals with specific genetic syndromes with or without family history of pancreatic cancer or members of families with multiple cases of pancreatic cancer, irrespective of genetic syndromes. In 2010 the Italia...
Source
#1Livia Archibugi (Sapienza University of Rome)H-Index: 13
#2Benedetta Graglia (Sapienza University of Rome)H-Index: 1
Last. Gabriele Capurso (UniSR: Vita-Salute San Raffaele University)H-Index: 56
view all 9 authors...
Abstract Background /Objectives: Pancreatic ductal adenocarcinoma (PDAC) has a higher incidence in men compared to women, although the difference in known risk factors cannot explain this disparity completely. Reproductive and hormonal factors have been demonstrated in pre-clinical studies to influence pancreatic carcinogenesis, but the few published data on the topic are inconsistent. The aim was to investigate the role of reproductive and hormonal factors on PDAC occurrence in women. Methods W...
Source
#1Monica Consolandi (UniSR: Vita-Salute San Raffaele University)H-Index: 1
#2Carlo Martini (UH: University of Helsinki)H-Index: 6
Last. Gabriele CapursoH-Index: 56
view all 7 authors...
: Background: In many cases of pancreatic adenocarcinoma (PDAC), the diagnosis comes as a surprise to the patient, who often faces a disease that is already at an advanced stage, with poor prognosis. The clinical visit during which the diagnosis is communicated together with the first information regarding the planned treatments is of paramount importance. We hypothesize that the clarity of such information can influence patients' engagement and thus their level of compliance. Aims: This study a...
1 CitationsSource
#1Jeyakumar R. Apollos (Dumfries and Galloway Royal Infirmary)H-Index: 2
#2Sharukh Sami (Dumfries and Galloway Royal Infirmary)H-Index: 1
Last. Angus McFadyenH-Index: 31
view all 5 authors...
Abstract Background Pancreatic ductal adenocarcinomas are poor prognostic cancers accounting for 3% of all cancer cases in the UK. They often present late in the course of the disease process with non-specific symptoms, including gastro-intestinal(GI) symptoms. Delays in diagnosis occur when investigations are carried out in a primary care setting for GI symptoms. The aim of this study was to assess delays in pancreatic cancer diagnosis when patients were referred for GI investigations and evalu...
2 CitationsSource