SI‐CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor‐associated macrophages

Chitinase‐like proteins (CLP) are chitin‐binding proteins that lack chitin hydrolyzing activity, but possess cytokine‐like and growth factor‐like properties, and play crucial role in intercellular crosstalk. Both human and mice express two members of CLP family: YKL‐40 and stabilin‐1 interacting chitinase‐like protein (SI‐CLP). Despite numerous reports indicating the role of YKL‐40 in the support of angiogenesis, tumor cell proliferation,...