Medications associated with fracture risk in patients with rheumatoid arthritis.

Published on Sep 1, 2021in Annals of the Rheumatic Diseases16.102
· DOI :10.1136/ANNRHEUMDIS-2019-216262
Yi-Sheng Liou7
Estimated H-index: 7
,
Tsung-Kun Lin3
Estimated H-index: 3
+ 1 AuthorsGwo-Ping Jong7
Estimated H-index: 7
Sources
Abstract
Statins have been widely used to control dyslipidaemia, and there is strong evidence for beneficial effects for patients at risk for cardiovascular diseases.1 2 In particular, statins may influence bone metabolism by increasing bone formation.3 4 Recently, Ozen et al 5 reported that medication with opioids, selective serotonin reuptake inhibitors, and glucocorticoids were associated with an increased risk of osteoporosis-related site fractures (vertebra, hip, forearm and humerus) in patients with rheumatoid arthritis, whereas statins and tumour necrosis factor-α inhibitors were associated with a decreased risk of vertebral fractures. These findings were published in the August 2019 issue of the Annals of the Rheumatic Diseases . Certainly, the findings of Ozen et al 5 will be significant for clinicians; however, four points remain unaddressed that we would like to communicate with the authors. First, the prevalence of osteoporotic fracture has been reported to be significantly higher in patients with chronic diseases compared …
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We appreciate the interest shown by Dr Chen1 concerning our recent study on medications associated with fracture risk in patients with rheumatoid arthritis (RA).2 We would like to clarify some issues Chen et al indicated. First, we agree that osteoporotic fractures are more common in patients with inflammatory diseases. However, in our study, we excluded all patients with prevalent fractures to estimate the …
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