Effectiveness of Cyclosporine-steroid Treatment after Cataract Surgery according to Dry Eye Severity

Published on Sep 15, 2019in Journal of The Korean Ophthalmological Society
· DOI :10.3341/JKOS.2019.60.9.821
Jae Yeong Park2
Estimated H-index: 2
(PNU: Pusan National University),
Sang Cheol Yang3
Estimated H-index: 3
(PNU: Pusan National University)
+ 3 AuthorsJong Soo Lee17
Estimated H-index: 17
(PNU: Pusan National University)
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#2Tara Moore (Ulster University)H-Index: 19
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Abstract Aim To assess the effect of cyclosporine-A (CsA) 0.05% ophthalmic emulsion on corneal sensation and ocular surface problems following cataract surgery. Design Prospective, randomized, double masked clinical trial. Methods Consecutive case series of patients attending for bilateral cataract surgery. Subject's eyes were randomized to receive either topical CsA or carboxymethylcellulose 0.5% (CMC) eye drops twice daily for one month following routine cataract surgery. Subjective and object...
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#1Anthony J. Bron (University of Oxford)H-Index: 62
Dry eye diseases are a group of disorders that share a mechanism by which tear hyperosmolarity at the surface of the eye leads to inflammatory ocular surface damage. The disease is conveniently classified according to how tear hyperosmolarity is brought about, either by reduced lacrimal secretion, ADDE, or by increased tear evaporation, EDE, measured under standard conditions. Because both conditions are the result of evaporative water loss, they may be triggered or worsened by exposure to desic...
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#1Ngamjit Kasetsuwan (Chula: Chulalongkorn University)H-Index: 9
#2Vannarut Satitpitakul (Chula: Chulalongkorn University)H-Index: 10
Last. Supharat Jariyakosol (Chula: Chulalongkorn University)H-Index: 4
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Purpose To evaluate the incidence and severity pattern of dry eye after phacoemulsification. Setting King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Design Prospective descriptive study. Methods Samples were collected from ninety-two uncomplicated cataract patients who were 18 years old or older. Dry eye incidence and pattern were analyzed at days 0, 7, 30 and 90 after phacoemulsification using (1) Ocular Surface Disease Index (OSDI) questionnaire, (2) tear break up time (TBUT), (3) Oxf...
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#1Hyo Seok LeeH-Index: 11
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Last. Kyung Chul YoonH-Index: 23
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PURPOSE: To evaluate the effect of topical cyclosporine A 0.05% after laser epithelial keratomileusis (LASEK). METHODS: This retrospective nonrandomized comparative analysis was performed in 40 patients (80 eyes) with myopia who underwent flap-off LASEK. Twenty patients (group A) were treated with topical cyclosporine A 0.05% in combination with conventional treatment, and 20 patients (group B) received conventional treatment only. In each group, 10 patients had preoperative dry eye. Uncorrected...
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#1Yeon Woong Chung (Catholic University of Korea)H-Index: 3
#2Tae Hoon Oh (Catholic University of Korea)H-Index: 1
Last. Sung Kun Chung (Catholic University of Korea)H-Index: 3
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Cataract surgery is one of the most common ophthalmologic procedures and has a high rate of success. Postoperative complaints of dry eye symptoms may occur, including ocular soreness, pain, burning sensation and foreign body sensation [1-3]. Studies suggest that cataract surgery can lead to the presentation of dry eye signs and symptoms by a change in the ocular surface environment or there may be a pre-existing condition not recognized by the patient or physician [1-3]. Cyclosporine 0.05% is a ...
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#1Yeo Jue Byun (Yonsei University)H-Index: 5
#1Yeo-Jue ByunH-Index: 2
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PURPOSE: To compare the efficacy of topical cyclosporine 0.05% (tCsA) and combined treatment with 1% methylprednisolone acetate for the treatment of moderate-to-severe chronic dry eye. PATIENTS AND METHODS: Forty-four patients with moderate-to-severe dry eye who had not responded to conventional treatment were treated with tCsA for 3 months. Twenty-one subjects (Group 1) were treated with 1% methyl prednisolone acetate and tCsA for the initial 3 weeks, and treated with tCsA only thereafter, and ...
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#1Won Choi (Chonnam National University)H-Index: 14
#2Kyung Chul Yoon (Chonnam National University)H-Index: 23
Last. Kyung-Chul Yoon (Chonnam National University)H-Index: 28
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#1John D. Sheppard (EVMS: Eastern Virginia Medical School)H-Index: 21
#2Stephen V. ScoperH-Index: 3
Last. Sandeep S. SamudreH-Index: 7
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Abstract Purpose: This retrospective, clinical comparative analysis describes differences in clinical signs and symptoms and medication tolerability between those patients who receive topical corticosteroids prior to initiation of topical cyclosporine 0.5% emulsion (tCSA) therapy for chronic dry eye disease (CDED) and those who received tCSA and were not first induced with corticosteroid drops. tCSA is the only approved medication for CDED. Stinging is the most common side effect of tCSA and rea...
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#1Esra Sahli (Ankara University)H-Index: 2
#2Banu M. HoşalH-Index: 15
Last. Hüseyin ÜstünH-Index: 4
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Purpose:To compare the clinical findings and the cytological grade of the disease before and after 6 months of topical cyclosporine A treatment in patients with dry eye.Setting:This single-center prospective study was performed at the Department of Ophthalmology, Ankara University School of Medicine
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Objective To evaluate the efficacy and safety of two different concentrations of cyclosporine A (CsA) in aqueous solution compared to vehicle in patients with dry eye syndrome. Design Multicentre, randomised, double-masked, vehicle-controlled, clinical trial. Methods A total of 183 patients were enrolled and randomised to either CsA 1% (group A), CsA 0.05% (group B) or vehicle only (group C). The main objective was to evaluate the efficacy of CsA aqueous solution in the reduction of signs and sy...
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#1James S. Wolffsohn (Aston University)H-Index: 61
#2Sonia Trave-Huarte (Aston University)
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Abstract Purpose To examine clinical management and prescribing patterns for dry eye disease (DED), in relation to severity and subtype, by eyecare practitioners across the globe. Methods An online-anonymous cross-sectional survey (on Qualtrix) translated into 14 languages was distributed to eyecare practitioners across the globe. The survey included six questions around the management of DED, in relation to severity and subtype. Result The survey was completed by 1139 eyecare professionals (37%...
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