Glucocorticoid regulation of amino acid transport in primary human trophoblast cells

Volume: 63, Issue: 4, Pages: 239 - 248
Published: Nov 1, 2019
Abstract
Excess maternal glucocorticoids reduce placental amino acid transport and fetal growth, but whether these effects are mediated directly on the syncytiotrophoblast remains unknown. We hypothesised that glucocorticoids inhibit mechanistic target of rapamycin (mTOR) signaling and insulin-stimulated System A amino acid transport activity in primary human trophoblast (PHT) cells. Syncytialised PHTs, isolated from term placentas ( n = 15), were...
Paper Details
Title
Glucocorticoid regulation of amino acid transport in primary human trophoblast cells
Published Date
Nov 1, 2019
Volume
63
Issue
4
Pages
239 - 248
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