Introducing Information on Saliva Microbiota into Toxicity Modeling: Preliminary Results from a Trial

A mono-institutional trial was set up to investigate the role of saliva/gut microbiota (MB) in toxicity (tox) after RT for head & neck (HNC) and prostate cancers. We here focus on introduction of information on saliva MB into a normal tissue complication probability model (NTCP) for acute oral mucositis (OM) in HNC. One hundred thirty consecutive HNC patients (pts) receiving either postoperative (60-66 Gy @2Gy/fr) or radical IMRT (70 Gy...