Molecular Encapsulation of Cinnamaldehyde within Cyclodextrin Inclusion Complex Electrospun Nanofibers: Fast-Dissolution, Enhanced Water Solubility, High Temperature Stability, and Antibacterial Activity of Cinnamaldehyde.

Published on Sep 11, 2019in Journal of Agricultural and Food Chemistry4.192
· DOI :10.1021/ACS.JAFC.9B02789
Zehra Irem Yildiz13
Estimated H-index: 13
(Bilkent University),
Mehmet Emin Kilic9
Estimated H-index: 9
(Bilkent University)
+ 1 AuthorsTamer Uyar59
Estimated H-index: 59
(Bilkent University)
The electrospinning nanofibers (NFs) of cinnamaldehyde inclusion complexes (ICs) with two different hydroxypropylated cyclodextrins (CDs), hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD), was successfully performed in order to produce cinnamaldehyde/CD-IC NFs without using additional polymer matrix. The inclusion complexation between cinnamaldehyde and hydroxypropylated CDs was studied by computational molecular modeling and the results suggested that HP-β-CD and HP-γ-CD can inclusion complexed with cinnamaldehyde at 1:1 and 2:1 (cinnamaldehyde:CD) molar ratio. Additionally, molecular modeling and phase solubility studies showed that water solubility of cinnamaldehyde dramatically increases with cyclodextrin inclusion complex (CD-IC) formation. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. Although cinnamaldehyde is highly volatile compound, cinnamaldehyde was effectively preserved with high loading ...
📖 Papers frequently viewed together
1 Citations
6 Citations
11 Authors (Neng Qiu, ..., Lijuan Chen)
48 Citations
Cited By19
#1Runan Zhao (HAU: Huazhong Agricultural University)H-Index: 2
#2Weiting Fu (HAU: Huazhong Agricultural University)H-Index: 1
Last. Yan Li (MOE: Chinese Ministry of Education)H-Index: 38
view all 6 authors...
Abstract null null The effect of cinnamaldehyde (CA) on the structure and properties of whey protein isolate (WPI) was investigated. The resultant WPI/CA complex was used as stabilizer to form emulsions and emulsion gels, which were used for the delivery and protection of β-carotene. The particle size and hydrophobicity of WPI solution increased and then decreased with the addition of CA. Circular dichroism showed that CA mainly changed the secondary structure of WPI, with increasing β-fold cont...
#1Niloufar Sharif (Shiraz University)H-Index: 5
#2Mohammad-Taghi Golmakani (Shiraz University)H-Index: 18
Last. Jahan B. Ghasemi (UT: University of Tehran)H-Index: 25
view all 5 authors...
Abstract null null Electrospinning process has been applied to fabricate hydroxypropyl-β-cyclodextrin fibers mat incorporating of cuminaldehyde. The inclusion complex formation between cuminaldehyde and hydroxypropyl-β-cyclodextrin was proved by computational molecular docking. The proton nuclear magnetic resonance results revealed that cuminaldehyde was present in final inclusion complex at 0.92:1 molecular ratio. Moreover, the presence of cuminaldehyde in the electrospun fibers in the inclusio...
#1Sara El kharraf (SIDI)H-Index: 1
#2Abdellah Farah (SIDI)H-Index: 15
Last. Maria Graça Miguel (University of the Algarve)H-Index: 27
view all 7 authors...
Abstract null null The polyvinyl alcohol nanofibers (PVA-NF) incorporating berberine-hydroxypropyl-β-cyclodextrin inclusion complex (Ber-IC) were prepared via electrospinning. The morphology of the nanofiber membrane was observed by scanning electron microscope (SEM). It is found that the diameters of nanofiber membrane decrease with the increasing berberine content. PVA-Ber-IC-NF have shown excellent antioxidant ability, and its radical scavenging ability is 87.71±0.04%. The Agar diffusion assa...
#1Andrea Dodero (UniGe: University of Genoa)H-Index: 10
#2Guy Schlatter (UDS: University of Strasbourg)H-Index: 25
Last. Maila Castellano (UniGe: University of Genoa)H-Index: 18
view all 5 authors...
Abstract The present review discusses the use of cyclodextrins and their derivatives to prepare electrospun nanofibers with specific features. Cyclodextrins, owing to their unique capability to form inclusion complexes with hydrophobic and volatile molecules, can indeed facilitate the encapsulation of bioactive compounds in electrospun nanofibers allowing fast-dissolving products for food, biomedical, and pharmaceutical purposes, filtering materials for wastewater and air purification, as well a...
3 CitationsSource
#1Hiroyuki TerashimaH-Index: 4
#2Atsushi Yamamoto (Chubu University)H-Index: 19
Last. Shuji Kodama (Tokai University)H-Index: 18
view all 7 authors...
Cyclodextrins and their derivatives have been used for chiral HPLC selectors, while they are costly to use as mobile phase additives in HPLC. Here, we report application of phenyl column coated permanently with methylated β-cyclodextrin for chiral HPLC. A 0.1% (v/v) phosphoric acid solution containing 1 M NaCl and 0.5% (w/v) methylated β-cyclodextrin was subjected to a phenyl column at a flow rate of 0.5 mL/min at 30 °C for 2 h. Using the precoating phenyl column, all the enantiomers of the four...
#1Xinyu Sun (NWAFU: Northwest A&F University)H-Index: 8
#2Lihua Li (NWAFU: Northwest A&F University)H-Index: 2
Last. Li Wang (NWAFU: Northwest A&F University)H-Index: 44
view all 9 authors...
Herein, a collaborative precise antibacterial wound healing therapy nanoplatform integrating drug-food homologous bioactive molecule (cinnamaldehyde, CA) with photothermal therapy (PTT) is presented. Copper-gallic acids-cinnamaldehyde-polydopamine nanorods (Cu-GA-CA-PDA NRs) with near-infrared light (NIR)-controlled CA release property are fabricated, which also integrate CA and photothermal synergistic sterilization, as well as antioxidant, anti-inflammatory, and anti-infection capacities. The ...
#1Yeli Wang (ZJSU: Zhejiang Gongshang University)
#2Zian Deng (ZJSU: Zhejiang Gongshang University)H-Index: 1
Last. Xianrui Liang (Zhejiang University of Technology)H-Index: 2
view all 7 authors...
Abstract Improving solubility and administration route of isoflavone formononetin (FMN) are critical factors to improve its bioavailability in the oral cavity. This study fabricated fast-dissolving nanofibers containing FMN/methyl-β-cyclodextrin (FMN/Me-β-CD) inclusion complex. The solubility of FMN could be increased by approximately 50 times at 20 mM aqueous Me-β-CD. Interactions and thermodynamic parameters of the host-guest inclusion complex were studied by a fluorescence quenching method. T...
#1Shuang Gao (NEAU: Northeast Agricultural University)H-Index: 11
#2Yanyan Liu (NEAU: Northeast Agricultural University)H-Index: 6
Last. Li-Xia Zhao (NEAU: Northeast Agricultural University)H-Index: 11
view all 7 authors...
Abstract The electrospinning of thiram/hydroxypropyl-β-cyclodextrin inclusion complex nanofiber (thiram/HPβCD-IC-NF) was produced for establishing a quick dissolving water-based drug delivery system. As a dithiocarbamate broad-spectrum fungicide, thiram is insoluble in water. High-concentration HPβCD solutions (180 %, w/v) were applied in thiram/HPβCD systems to implement electrospinning with no extra polymer matrix added. The formation of thiram/HPβCD-IC-NF was identified by Fourier transform i...
8 CitationsSource
#1Yao Hu (Jiangnan University)H-Index: 5
#2Chao Qiu (Jiangnan University)H-Index: 9
Last. Zhengyu Jin (Jiangnan University)H-Index: 64
view all 7 authors...
Abstract Background Natural phytochemicals suffer from poor aqueous solubility and storage stability as well as demonstrate limited bioaccessibility; thus, their effectiveness as food ingredients is severely restricted. The construction of cyclodextrin inclusion complexes (CICs) allows naturally derived phytochemicals with enhanced solubility and stability in various environmental situations to maintain their biological activity during food processing and storage. Scope and approach With the use...
2 CitationsSource