Molecular Encapsulation of Cinnamaldehyde within Cyclodextrin Inclusion Complex Electrospun Nanofibers: Fast-Dissolution, Enhanced Water Solubility, High Temperature Stability, and Antibacterial Activity of Cinnamaldehyde.

Published on Sep 11, 2019in Journal of Agricultural and Food Chemistry4.192
· DOI :10.1021/ACS.JAFC.9B02789
Zehra Irem Yildiz13
Estimated H-index: 13
(Bilkent University),
Mehmet Emin Kilic9
Estimated H-index: 9
(Bilkent University)
+ 1 AuthorsTamer Uyar59
Estimated H-index: 59
(Bilkent University)
Sources
Abstract
The electrospinning nanofibers (NFs) of cinnamaldehyde inclusion complexes (ICs) with two different hydroxypropylated cyclodextrins (CDs), hydroxypropyl-β-cyclodextrin (HP-β-CD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD), was successfully performed in order to produce cinnamaldehyde/CD-IC NFs without using additional polymer matrix. The inclusion complexation between cinnamaldehyde and hydroxypropylated CDs was studied by computational molecular modeling and the results suggested that HP-β-CD and HP-γ-CD can inclusion complexed with cinnamaldehyde at 1:1 and 2:1 (cinnamaldehyde:CD) molar ratio. Additionally, molecular modeling and phase solubility studies showed that water solubility of cinnamaldehyde dramatically increases with cyclodextrin inclusion complex (CD-IC) formation. The HP-β-CD has shown slightly stronger binding with cinnamaldehyde when compared to HP-γ-CD for cinnamaldehyde/CD-IC. Although cinnamaldehyde is highly volatile compound, cinnamaldehyde was effectively preserved with high loading ...
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