Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.

Published on Sep 11, 2019in Graefes Archive for Clinical and Experimental Ophthalmology3.117
路 DOI :10.1007/S00417-019-04467-Z
Seung-Hyun Jung21
Estimated H-index: 21
(Catholic University of Korea),
Young Chun Lee9
Estimated H-index: 9
(Catholic University of Korea)
+ 1 AuthorsHye-Young Shin10
Estimated H-index: 10
(Catholic University of Korea)
Sources
Abstract
Background Previous studies have reported the association of HK2 and NCK2 genes with normal-tension glaucoma (NTG) in Japan, but there has been no follow-up study in other countries, so the relevance of these genes to NTG appears uncertain at present. Thus, we investigated the relationship between the HK2 and NCK2 genes and NTG in a Korean NTG cohort.
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#5Kyle J. Foreman (Imperial College London)H-Index: 61
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#1Sarah F. Janssen (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 10
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Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy triggered by both environmental and genetic risk factors. Several ocular tissues, including the ciliary body, trabecular meshwork and optic nerve head, and perhaps even brain tissues, are involved in a chain of pathological events leading to POAG. Genetic risk evidence for POAG came from family linkage-studies implicating a small number of disease genes (MYOC, OPEN, WDR36). Recent Genome Wide Association Studies (...
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#1Dong Shi (PRC: China Medical University (PRC))H-Index: 7
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Although family studies and genome-wide association studies have shown that genetic factors play a role in glaucoma, it has been difficult to identify the specific genetic variants involved. We tested 669 single nucleotide polymorphisms (SNPs) from the region of chromosome 2 that includes the GLC1B glaucoma locus for association with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) in the Japanese population. We performed a two-stage case-control study. The first cohort consi...
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#1Martha Kim (SNU: Seoul National University)H-Index: 9
#2Tae Woo Kim (SNU: Seoul National University)H-Index: 50
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Purpose To investigate the risk factors for primary open-angle glaucoma (POAG) in the Namil study population.
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#1Jennifer Round (Yale University)H-Index: 3
#2Hui Sun (Yale University)H-Index: 1
Abstract Slits are multifunctional guidance cues, capable of triggering neurite repulsion, extension, or branching, depending on cell type and developmental context. While the Robo family of Slit receptors is a well-established mediator of axon repulsion, a role for Robos in Slit-mediated neurite growth and branching is not well defined, and the signaling molecules that link Robo to the cytoskeletal changes that drive neurite outgrowth are not well characterized in vertebrates. We show that Slit...
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#1Chang-Sik Kim (CNU: Chungnam National University)H-Index: 14
#2Gong Je Seong (Yonsei University)H-Index: 33
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#1Ya Xing Wang (Capital Medical University)H-Index: 58
#2Liang Xu (Capital Medical University)H-Index: 69
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Purpose To assess the prevalence of glaucoma in adult Chinese. Design Population-based study. Methods The Beijing Eye Study in 2001 included 4439 subjects with an age of 40+ years. Glaucoma was determined using the ISGEO (International Society of Geographical and Epidemiological Ophthalmology) classification scheme. Results Glaucoma was detected in 158 subjects (3.7%, 95% confidence interval [CI] 3.1%鈥4.2%), in which open-angle glaucoma (OAG), primary angle-closure glaucoma (PACG), and secondary...
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#1Keun Jae Ahn (Yonsei University)H-Index: 10
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#1M Akiyama (YCU: Yokohama City University)H-Index: 1
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Aims: The aim of this study was to investigate the association between normal tension glaucoma and the candidate disease locus glaucoma 1, open angle, B (GLC1B) on chromosome 2. There are many reports describing the results of association or linkage studies for primary open angle glaucoma (POAG), with GLC1B as one of the loci associated with normal or moderately elevated intraocular pressure. However, there are few reports about the association of genes or defined genomic regions with normal ten...
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Whole-genome association studies (WGAS) bring new computational, as well as analytic, challenges to researchers. Many existing genetic-analysis tools are not designed to handle such large data sets in a convenient manner and do not necessarily exploit the new opportunities that whole-genome data bring. To address these issues, we developed PLINK, an open-source C/C++ WGAS tool set. With PLINK, large data sets comprising hundreds of thousands of markers genotyped for thousands of individuals can ...
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Glaucoma, the world鈥檚 leading cause of irreversible blindness, is a complex disease, with differential presentation as well as ethnic and geographic disparities. The multifactorial nature of glaucoma complicates the study of genetics and genetic involvement in the disease process. This review synthesizes the current literature on glaucoma and genetics, as stratified by glaucoma subtype and ethnicity. Primary open-angle glaucoma (POAG) is the most common cause of glaucoma worldwide, with the only...
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