Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib
Abstract
Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP inhibitor with a favourable safety profile in comparison to clinically used radiosensitisers including cisplatin when used as single agent. However, data on safety, tolerability and efficacy of olaparib in combination with radiotherapy are...
Paper Details
Title
Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib
Published Date
Sep 10, 2019
Journal
Volume
19
Issue
1
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