<p>Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy</p>

Volume: Volume 12, Pages: 1811 - 1820
Published: Sep 1, 2019
Abstract
Diabetic nephropathy (DN) is a progressive microvascular complication of diabetes mellitus (DM), driven largely by podocyte apoptosis. The cysteine protease Calpain 10 is known to augment apoptosis and necrosis, and is a potential therapeutic target in DN.Type 2 diabetes was induced in SD rats by high-fat diet (HFD) feeding and streptozotocin (STZ) injections, and simulated in vitro by culturing conditionally immortalized mouse podocytes in...
Paper Details
Title
<p>Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy</p>
Published Date
Sep 1, 2019
Volume
Volume 12
Pages
1811 - 1820
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