Abstract P104: Activation of Endoplasmic Reticulum Stress and Thrombospondin-1 Anti-Angiogenic Mechanisms in Placentas of Hypertensive Mice

Background: Thrombospondin-1 (Thbs1) is an anti-angiogenic focal adhesion glycoprotein. It binds to receptors CD36, LRP1 and CD47 activating anti-proliferative and anti-migratory mechanisms. Pre-eclampsia (PE) is characterized by poor placenta perfusion and angiogenesis, which is stimulated by oxidant and endoplasmic reticulum (ER) stresses contributing to placental insufficiency. ER stress has also been linked to Thbs1 anti-angiogenic actions....