A rare case of pulmonary Kaposi sarcoma presented with respiratory failure

Published on Sep 5, 2019in Journal of Community Hospital Internal Medicine Perspectives
· DOI :10.1080/20009666.2019.1640017
Elham Vosoughi (San Joaquin General Hospital), Chirag A. Sheth1
Estimated H-index: 1
(San Joaquin General Hospital)
+ 1 AuthorsMohsen Saadat3
Estimated H-index: 3
(San Joaquin General Hospital)
Sources
Abstract
ABSTRACTKaposi sarcoma (KS) is the most commonly diagnosed malignancy in HIV-infected patients. With new treatments, incidence and severity of KS have significantly decreased.A 57-year-old African ...
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#1Kathryn E. RoyseH-Index: 6
#2Firas El Chaer (BCM: Baylor College of Medicine)H-Index: 8
Last. Elizabeth Y. Chiao (BCM: Baylor College of Medicine)H-Index: 26
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Objective Geographic and racial disparities may contribute to variation in the incidence and outcomes of HIV-associated cancers in the United States. Method Using the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed Kaposi sarcoma (KS) incidence and survival by race and geographic region during the combined antiretroviral therapy era. Reported cases of KS in men from 2000 to 2013 were obtained from 17 SEER cancer registries. Overall and age-standardized KS incidence rates...
19 CitationsSource
#1Marilia Rita Pinzone (University of Catania)H-Index: 19
Last. Giuseppe Nunnari (University of Catania)H-Index: 32
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The human gammaherpesvirus family includes Epstein-Barr virus (EBV) and human herpesvirus (HHV)-8, also known as Kaposi sarcoma–associated herpesvirus (KSHV). In human immunodeficiency virus (HIV)-infected patients, both EBV and KSHV have been implicated in the development of a wide range of tumors. KSHV-associated diseases include Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). EBV has been associated with the development of several malignancies, ...
41 CitationsSource
#1Oluwatoyin F Gbabe (Stellenbosch University)H-Index: 1
#2Charles I Okwundu (Stellenbosch University)H-Index: 12
Last. Esther E. Freeman (Harvard University)H-Index: 20
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Background Kaposi's sarcoma remains the most common cancer in Sub-Saharan Africa and the second most common cancer in HIV-infected patients worldwide. Since the introduction of highly active antiretroviral therapy (HAART), there has been a decline in its incidence. However, Kaposi's sarcoma continues to be diagnosed in HIV-infected patients. Objectives To assess the added advantage of chemotherapy plus HAART compared to HAART alone; and the advantages of different chemotherapy regimens in HAART ...
51 CitationsSource
#1L. La Ferla (University of Catania)H-Index: 1
#2Marilia Rita Pinzone (University of Catania)H-Index: 19
Last. Bruno Cacopardo (University of Catania)H-Index: 29
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Kaposiʼs sarcoma (KS) is a mul - ticentric angioproliferative cancer of endothelial origin typically occurring in the context of im - munodeficiency, i.e. coinfection with Human Im - monodeficiency Virus (HIV) or transplantation. The incidence of KS has dramatically decreased in both US and Europe in the Highly Active Anti - retroviral Therapy (HAART) era. However, KS re - mains the second most frequent tumor in HIV-in - fected patients worldwide and it has become the most common cancer in Sub-S...
65 Citations
#1Mary Cianfrocca (NU: Northwestern University)H-Index: 12
#2Sandra J. Lee (Harvard University)H-Index: 57
Last. Joseph A. Sparano (Albert Einstein College of Medicine)H-Index: 83
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BACKGROUND: Paclitaxel and pegylated liposomal doxorubicin (PLD) are active cytotoxic agents for the treatment of human immunodeficiency virus (HIV)-associated Kaposi sarcoma (KS). A randomized trial comparing the efficacy and toxicity of paclitaxel and PLD was performed, and the effects of therapy on symptom palliation and quality of life were determined. METHODS: Patients with advanced HIV-associated KS were randomly assigned to receive paclitaxel at a dose of 100 mg/m2 intravenously (iv) ever...
88 CitationsSource
#1Taisa Davaus Gasparetto (Federal Fluminense University)H-Index: 10
#2Edson Marchiori (Federal Fluminense University)H-Index: 51
Last. Luiz Felipe NobreH-Index: 16
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Kaposi sarcoma is a low-grade mesenchymal tumor involving blood and lymphatic vessels. There are four variants of this disease, each presenting a different clinical manifestation: classic or sporadic, African or endemic, organ transplant-related or iatrogenic, and AIDS-related or epidemic. Kaposi sarcoma is the most common tumor among patients with HIV infection, occurring predominantly in homosexual or bisexual men. The pulmonary involvement in Kaposi sarcoma occurs commonly in critically immun...
36 CitationsSource
#1Ryan J. Sullivan (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 62
#2Liron Pantanowitz (Tufts University)H-Index: 57
Last. Bruce J. Dezube (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 61
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Kaposi sarcoma-associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. These conditions are also intimately associated with human immunodeficiency virus infection, and important synergistic interactions between these 2 viruses have been described. Despite differences in viral gene expression patterns in each condition, Kaposi sarcoma-associated herpesvirus encodes similar oncog...
123 CitationsSource
#1Manish Joshi (MCW: Medical College of Wisconsin)H-Index: 3
#2Natalia MarkelovaH-Index: 2
Last. Ralph M. SchapiraH-Index: 13
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9 CitationsSource
#1Manish Joshi (MCW: Medical College of Wisconsin)H-Index: 3
#2Natalia Markelova (MCW: Medical College of Wisconsin)H-Index: 1
Last. Ralph M. Schapira (MCW: Medical College of Wisconsin)H-Index: 13
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10 CitationsSource
#1Carlo PalmieriH-Index: 33
#2Tony DhillonH-Index: 14
Last. Mark BowerH-Index: 74
view all 8 authors...
Objective Since the introduction of highly active antiretroviral therapy (HAART) there has been a dramatic reduction in the incidence of Kaposi sarcoma (KS) and an improvement in survival. We wished to examine whether the outcome in pulmonary KS (pKS) has also altered. Methods In a single-institution cohort of 1140 HIV-positive patients with KS, 305 patients were diagnosed in the HAART era (1996–2004). We examined the clinicopathological features and outcomes of these patients, of whom 25 had pK...
30 CitationsSource
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#1Lucia BrambillaH-Index: 21
#2Giovanni GenoveseH-Index: 13
Last. Piergiacomo Calzavara Pinton (University of Brescia)H-Index: 9
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Kaposi's sarcoma (KS) is a lymphangioproliferative disorder associated with Human herpesvirus 8 (HHV8) infection. Four clinical subtypes are recognized: classic, endemic, epidemic (HIV-related) and iatrogenic. KS diagnosis is based on clinical features, histopathological assessment, and HHV8 serology. Classic KS is usually skin-limited and has a chronic course, while the iatrogenic variant may show mucosal, nodal or visceral involvement. Clinical staging is fundamental to guide the management. L...
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