Generation ofStreptomyces hygroscopicuscell factories with enhanced ascomycin production by combined elicitation and pathway‐engineering strategies

Volume: 116, Issue: 12, Pages: 3382 - 3395
Published: Sep 10, 2019
Abstract
Ascomycin (FK520) is a macrocyclic antibiotic that also exhibits antifungal and immunosuppressive activity. However, its relatively low titer and yield have hampered commercial application. Here, we have successfully constructed an efficient ascomycin-producing strain of Streptomyces hygroscopicus with high titer and yield, using a novel combinatorial engineering approach based on the identification of targets involved in both metabolic and...
Paper Details
Title
Generation ofStreptomyces hygroscopicuscell factories with enhanced ascomycin production by combined elicitation and pathway‐engineering strategies
Published Date
Sep 10, 2019
Volume
116
Issue
12
Pages
3382 - 3395
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