Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression
Abstract
Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression...
Paper Details
Title
Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression
Published Date
Sep 2, 2019
Journal
Volume
9
Issue
1
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