Noninvasive PET Imaging of CDK4/6 Activation in Breast Cancer
Abstract
The cell cycle is a progression of 4 distinct phases (G1, S, G2, and M), with various cycle proteins being essential in regulating this process. We aimed to develop a radiolabeled cyclin-dependent kinase 4/6 (CDK4/6) inhibitor for breast cancer imaging. Our transfluorinated analog (18F-CDKi) was evaluated and validated as a novel PET imaging agent to quantify CDK4/6 expression in estrogen receptor (ER)-positive human epidermal growth factor...
Paper Details
Title
Noninvasive PET Imaging of CDK4/6 Activation in Breast Cancer
Published Date
Sep 3, 2019
Volume
61
Issue
3
Pages
437 - 442
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