Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks
Abstract
Four drug-conjugated poly(2-alkyl-2-oxazoline) (PAOx) networks with different hydrophobicity were synthesized via copolymerization of either 2-methyl-, 2-ethyl-, 2-propyl- or 2-butyl-2-oxazoline with the functional monomer, 2-dec-9-enyl-2-oxazoline. The incorporation of a labile ester linkage between the polymer and the drug benazepril allowed for sustained drug release over periods of months with the release rates strongly depending on the...
Paper Details
Title
Influence of side-chain length on long-term release kinetics from poly(2-oxazoline)-drug conjugate networks
Published Date
Nov 1, 2019
Journal
Volume
120
Pages
109217 - 109217
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