Cisplatin-Induced Ototoxicity: Updates on Molecular Targets
Abstract
Cis-diamminedichloridoplatinum (II) (cisplatin) is a chemotherapeutic drug currently prescribed for the treatment of many types of human cancer, but its use is associated with numerous adverse effects, one of which is ototoxicity. Cisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress,...
Paper Details
Title
Cisplatin-Induced Ototoxicity: Updates on Molecular Targets
Published Date
Dec 1, 2019
Journal
Volume
25
Issue
12
Pages
1123 - 1132
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