Genome-wide discovery of hidden genes mediating known drug-disease association

Pages: 749762
Published: Sep 25, 2020
Abstract
Identifying of hidden genes mediating Known Drug-Disease Association (KDDA) is of great significance for understanding disease pathogenesis and guiding drug repurposing. Here, we present a novel computational tool, called KDDANet, for systematic and accurate uncovering hidden genes mediating KDDA from the perspective of genome-wide gene functional interaction network. By implementing minimum cost flow optimization, combined with depth first...
Paper Details
Title
Genome-wide discovery of hidden genes mediating known drug-disease association
Published Date
Sep 25, 2020
Journal
Pages
749762
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