Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial

Aims To evaluate the safety and pharmacokinetics of naringenin in healthy adults consuming whole‐orange ( Citrus sinensis ) extract. Methods and methods In a single‐ascending‐dose randomized crossover trial, 18 adults ingested doses of 150 mg (NAR150), 300 mg (NAR300), 600 mg (NAR600) and 900 mg (NAR900) naringenin or placebo. Each dose or placebo was followed by a wash‐out period of at least 1 week. Blood safety markers were evaluated pre‐dose...