Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis
Abstract
Activation of hepatocyte cannabinoid receptor-1 (CB1R) by hepatic stellate cell (HSC)-derived 2-arachidonoylglycerol (2-AG) drives de novo lipogenesis in alcoholic liver disease (ALD). How alcohol stimulates 2-AG production in HSCs is unknown. Here, we report that chronic alcohol consumption induced hepatic cysteine deficiency and subsequent glutathione depletion by impaired transsulfuration pathway. A compensatory increase in hepatic...
Paper Details
Title
Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis
Published Date
Nov 1, 2019
Journal
Volume
30
Issue
5
Pages
877 - 889.e7
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