Progress in the polymer-paclitaxel conjugate

Paclitaxel (PTX) is one of the natural products used as first- or second-line treatment of cancer. It has a wide spectrum of activity against various cancer types, but low solubility in water, and toxicity to normal tissues such as hypersensitivity reaction and neuropathy limited its applications. The serious endeavors have been made to design and fabricate a more favorable nanoformulation lowering the inherent toxicity and side effects of PTX....