Primary Aldosteronism
Abstract
Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein-coupled inwardly rectifying potassium channel are a cause of primary aldosteronism. These mutations drive aldosterone excess, but their role in cell growth is undefined. Our objective was to determine the role of KCNJ5 mutations in adrenal cell proliferation and apoptosis. The Ki67 proliferative index was positively correlated with adenoma diameter in...
Paper Details
Title
Primary Aldosteronism
Published Date
Oct 1, 2019
Journal
Volume
74
Issue
4
Pages
809 - 816
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History