Association between vitamin D status in early pregnancy and atopy in offspring in a vitamin D deplete cohort

Published on May 1, 2020in Irish Journal of Medical Science1.1
· DOI :10.1007/S11845-019-02078-5
Maeve Smith1
Estimated H-index: 1
(UCD: University College Dublin),
Eileen C O'Brien9
Estimated H-index: 9
(UCD: University College Dublin)
+ 4 AuthorsFionnuala M. McAuliffe57
Estimated H-index: 57
(UCD: University College Dublin)
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Abstract
Background Vitamin D status may play a role in the development of atopic diseases due to its action on lung development and immune system development and function.
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References33
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#1C. M. Windrim (UCD: University College Dublin)H-Index: 1
#2David A. Crosby (UCD: University College Dublin)H-Index: 6
Last. Mary Higgins (UCD: University College Dublin)H-Index: 17
view all 6 authors...
Background Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pregnancy and lactation.
4 CitationsSource
#1JoAnn E. MansonH-Index: 297
#2Patsy M. BrannonH-Index: 21
Last. Christine L. Taylor (NIH: National Institutes of Health)H-Index: 7
view all 4 authors...
The claim that large proportions of North American and other populations are deficient in vitamin D is based on misinterpretation and misapplication of the Institute of Medicine reference values for nutrients — misunderstandings that can adversely affect patient care.
156 CitationsSource
#1Mairead KielyH-Index: 62
#2J. Y. ZhangH-Index: 5
Last. Louise C. Kenny (UCC: University College Cork)H-Index: 69
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Associations between vitamin D and pregnancy outcomes have been inconsistent.We described the distribution of 25-hydroxyvitamin D3 [25(OH)D3], 3-epi-25(OH)D3, and 25(OH)D2 in early pregnancy and investigated associations with pre-eclampsia and small-for-gestational-age (SGA) birth, which are indicative of uteroplacental dysfunction.The SCOPE (Screening for Pregnancy Endpoints) Ireland prospective pregnancy cohort study included 1768 well-characterized low-risk, nulliparous women resident at 52°N...
72 CitationsSource
#1Erika von Mutius (LMU: Ludwig Maximilian University of Munich)H-Index: 99
#2Fernando D. Martinez (UA: University of Arizona)H-Index: 123
In most large cities in the Northern hemisphere in the late 19th and early 20th centuries, rickets was an enormous public health problem, mainly because exposure to sunlight was limited, particularly for children.1 German physicians noticed that daily administration of a tablespoon of cod liver oil could reverse rickets, a finding that led to the discovery of vitamin D, its structure, and function. In the United States, most of the milk supply is now voluntarily fortified with vitamin D, whereas...
19 CitationsSource
#1Augusto A. Litonjua (Harvard University)H-Index: 96
#2Vincent J. Carey (Harvard University)H-Index: 75
Last. Scott T. Weiss (Harvard University)H-Index: 168
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Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has been variably associated with these disorders in offspring. Objective To determine whether prenatal vitamin D (cholecalciferol) supplementation can prevent asthma or recurrent wheeze in early childhood. Design, Setting, and Participants The Vitamin D Antenatal Asthma Reduction Trial was a randomized, double-blind, placebo-controlled trial conducted in 3 centers across the United States. Enrollment began in ...
245 CitationsSource
#1Debra J. Palmer (University of Adelaide)H-Index: 17
#2Thomas Sullivan (University of Adelaide)H-Index: 38
Last. Maria Makrides (University of Adelaide)H-Index: 69
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Background In recent years the role of vitamin D status in early life on the development of allergic disease has generated much interest. The aim of this study was to determine whether cord blood vitamin D concentrations were associated with risk of early childhood allergic disease.
15 CitationsSource
#1Malachi J. McKennaH-Index: 29
#2Barbara MurrayH-Index: 13
Last. Mark KilbaneH-Index: 13
view all 4 authors...
Background The Institute of Medicine 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D specified higher intakes for all age groups compared to the 1997 report, but also cautioned against spurious claims about an epidemic of vitamin D deficiency and against advocates of higher intake requirements. Over 40 years, we have noted marked improvement in vitamin D status but we are concerned about hypervitaminosis D.
20 CitationsSource
#1Chike Onwuneme (UCD: University College Dublin)H-Index: 8
#2Fidelma MartinH-Index: 1
Last. Eleanor J. MolloyH-Index: 28
view all 11 authors...
Objective To assess the association between serum 25-hydroxyvitamin D (25OHD) levels and outcomes in preterm infants ( Study design Serum 25OHD was measured in mothers and their infants within 24 hours of birth, before the start of enteral vitamin D supplementation, and at discharge from the neonatal intensive care unit. We evaluated the associations between vitamin D status and various early preterm outcomes. Results Ninety-four preterm infants and their mothers were included; 92% of the infant...
47 CitationsSource
#1Bo L. Chawes (Copenhagen University Hospital)H-Index: 34
#2Klaus Bønnelykke (Copenhagen University Hospital)H-Index: 59
Last. Hans Bisgaard (Copenhagen University Hospital)H-Index: 105
view all 6 authors...
Background Epidemiological studies have suggested an association between maternal vitamin D dietary intake during pregnancy and risk of asthma and allergy in the offspring. However, prospective clinical studies on vitamin D measured in cord blood and development of clinical end-points are sparse.
77 CitationsSource
#1Mark KilbaneH-Index: 13
#2Myra O'KeaneH-Index: 6
Last. Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
view all 5 authors...
Introduction The Institute of Medicine (IOM) 2011 on dietary references intakes for calcium and vitamin D specified that a 25-hydroxyvitamin D (25OHD) level below 30 nmol/L indicated risk of deficiency and that a level above 125 nmol/L indicated risk of harm.
7 CitationsSource
Cited By4
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#1Yih-Chieh S. Chen (Brigham and Women's Hospital)
#2Hooman Mirzakhani (Brigham and Women's Hospital)H-Index: 13
Last. Benjamin J. Harshfield (Brigham and Women's Hospital)H-Index: 10
view all 14 authors...
Background null The role of prenatal vitamin D sufficiency and supplementation in the development of childhood aeroallergen sensitization and allergic rhinitis remains uncertain. null null null Objective null To describe the association of prenatal vitamin D sufficiency with childhood allergic outcomes in participants of the Vitamin D Antenatal Asthma Reduction Trial, a randomized controlled trial of prenatal vitamin D supplementation. null null null Methods null We included 414 mother–offspring...
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#1Franziska Roth-Walter (University of Veterinary Medicine Vienna)H-Index: 21
Iron deficiency is associated with atopy. Iron deficiency during pregnancy increases the risk of atopic diseases in children, while both allergic children and adults are more likely to have iron deficiency anemia. Immunologically, iron deficiency leads to activation of antigen-presenting cells, promotion of Th2 cells and enables antibody class switch in B cells. In addition, iron deficiency primes mast cells for degranulation, while an increase in their iron content inhibits their degranulation....
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OBJECTIVES Vitamin D plays an important role in the release of the placenta and implantation, and low levels are a risk factor for pre-eclampsia. Studies have also shown that symptomatic treatment of vitamin D3 deficiency can effectively reduce the risk of pre-eclampsia. In this study, vitamin D3 supplementation was performed on the risk of pre-eclampsia to observe its effect. METHODS From January 2016 to December 2018, 450 women with maternal treatment and delivery in our hospital underwent an ...
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