Self-emulsifying drug delivery systems comprising chlorhexidine and alkyl-EDTA: A novel approach for augmented antimicrobial activity

The aim of the study was to develop a self-emulsifying drug delivery systems (SEDDS) comprising chlorhexidine (CX) and monododecylamide-EDTA (alkyl-EDTA) exhibiting enhanced microbicidal properties. SEDDS containing 20% Captex 300, 45% Cremophor EL, 17% Tween 80 and 18% DMSO were loaded with 3% (m/v) alkyl-EDTA (FA) and formulations of 1% CX and 1.5% (m/v) alkyl-EDTA (FA-CX1% and FA-ED1.5%) were prepared separately as well as in combination...