Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy
Abstract
Hypercalcemia, one of the most common paraneoplastic syndromes, is generally caused by tumor secretion of parathyroid hormone-related protein (PTHrP). PTHrP isoforms exhibit a high degree of homology within the first 13 residues to the amino (N)-terminus of parathyroid hormone (PTH). Consequently, PTHrP interacts with the same G protein-coupled receptor as PTH and carries out similar skeletal and renal activity leading to receptor activator of...
Paper Details
Title
Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy
Published Date
Jan 1, 2020
Journal
Pages
1307 - 1333
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