Methicillin-resistant Staphylococcus aureus

Engineering

Staphylococcus aureus

Polymer chemistry

Bacteria

Biology

Metallurgy

Materials science

Wound dressing

In situ

Chemical engineering

Immunology

Polymer

Genetics

Organic chemistry

Self-healing hydrogels

Copolymer

Microbiology

Biocompatibility

Composite material

Ethylene oxide

Medicine

Chemistry

Ethylene glycol

Wound healing

ACS Nano

An in situ forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most in situ forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable in situ forming hydrogel composed of poly(N-isopropylacrylamide166-co-n-butyl acrylate9)-poly(ethylene glycol)-poly(N-isopropylacrylamide166-co-n-butyl acrylate9) copolymer (P(NIPAM166-co-nBA9)-PEG-P(NIPAM166-co-nBA9), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol-gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant Staphylococcus aureus (MRSA) of this PEP-AG hydrogel wound dressing are confirmed in vitro and in vivo, which could transparently promote the healing of a MRSA-infected skin defect.

Thermoresponsive <i>in Situ</i> Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant <i>Staphylococcus aureus</i> Infected Wound Healing

Thermoresponsive in Situ Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing