CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity
Abstract
CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of endothelial tip cell activity in angiogenesis. Microvessel networks and directional vascular cell migration patterns were deformed in ccn1-knockdown zebrafish embryos. CCN1 activated VEGFR2 and downstream MAPK/PI3K signalling pathways, YAP/TAZ, as well as Rho effector mDia1 to enhance tip cell...
Paper Details
Title
CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity
Published Date
Aug 20, 2019
Journal
Volume
8
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