FUNCTIONAL ANALYSIS OF CD99 UPREGULATION IN ACUTE MYELOID LEUKEMIA

Outcome of patients with Acute Myeloid Leukemia (AML) remains dismal and the need for new therapies is high. We recently found CD99 to be upregulated in AML and showed that CD99 loss of function by siRNA or anti-CD99 antibody decreased proliferation of AML cells. Here, we investigate the functional role of CD99 wild type isoform (WT) in AML with the hypothesis that CD99 ectopic expression results in more aggressive leukemia. null We found that...