RETINOIC ACID RECEPTOR GAMMA ACTIVITY IN ENDOTHELIAL CELLS REGULATES B LYMPHOPOIESIS, ERYTHROPOIESIS, PLATELET PRODUCTION, VASCULATURE STRUCTURE AND ADIPOCYTE SIZE IN A SEX-DEPENDENT MANNER

We have previously shown that mice null for the vitamin A receptor, retinoic acid receptor gamma (Rarg-/- mice) developed a myeloproliferative-like syndrome, accompanied by bone marrow (BM) B lymphopenia and reduced BM erythrocytes, and we have shown that all of these phenotypes were microenvironment-induced. Here, we deleted Rarg in tamoxifen-inducible Cdh5(PAC)CreERT2 (VE-Cadherin)-expressing endothelial cells (ECs) in 3-week old mice and...