Random biopsy of the neosquamous epithelium is a waste of time and money

“You can observe a lot just by watching.”–Yogi Berra The past decade has demonstrated that endoscopic eradication therapy (EET), combining radiofrequency ablation (RFA) and endoscopic resection (ER), is the standard of care for patients with Barrett’s esophagus (BE)–related neoplasia. Although this approach boasts high rates of reversion to squamous epithelium and a low risk of subsequent death resulting from adenocarcinoma,1Cotton C.C. Wolf...