Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.

Volume: 28, Issue: 7, Pages: 1845
Published: Aug 13, 2019
Abstract
Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPase Dynamin-related protein 1 (Drp1). However, the role of Drp1 in the setting of endogenous oncogenic KRas remains unknown. Here, we show that Drp1 is...
Paper Details
Title
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
Published Date
Aug 13, 2019
Volume
28
Issue
7
Pages
1845
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