Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction

Significance We describe the convergence of autophagy with YAP/TAZ, 2 highly related transcriptional regulators playing essential roles in cell plasticity for tissue regeneration and cancer. We show that a key event in autophagy, the fusion of autophagosomal vesicles with lysosomes, is transcriptionally regulated by YAP/TAZ. At least in part, this is mediated by the YAP/TAZ target Armus, a protein of the RAB-GAP family. Consistently with YAP/TAZ...