Mimicked hybrid hydrogel based on gelatin/PVA for tissue engineering in subchondral bone interface for osteoarthritis surgery

Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage and extends to the subchondral bone. The interface between these soft and hard tissues has a significant role in OA. In this work, gelatin/PVA hydrogels in different ratios of 100:0, 70:30, 50:50, 30:70, and 0:100 were prepared by chemical and freeze-thaw physical crosslinking. The molecular organization and morphology were characterized and observed by FTIR and SEM,...