Membrane‐initiated estrogen signaling in prostate cancer: A route to epithelial‐to‐mesenchymal transition
Abstract
The plasma membrane (PM) is considered as a major druggable site. More than 50% of the existing drugs target PM proteins. In the wake of emerging data indicating a key role of estrogens in prostate cancer (PCa) pathogenesis, the study was undertaken to explore whether the estrogen binding sites exist on the PM and if such sites are functionally relevant in PCa. Estradiol (E2) binding to the PM was detected in androgen‐dependent (LNCaP),...
Paper Details
Title
Membrane‐initiated estrogen signaling in prostate cancer: A route to epithelial‐to‐mesenchymal transition
Published Date
Aug 14, 2019
Journal
Volume
58
Issue
11
Pages
2077 - 2090
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