GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Abstract
Summary null Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. We found that inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of...
Paper Details
Title
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Published Date
Aug 22, 2019
Journal
Volume
178
Issue
5
Pages
1231
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