Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Volume: 10, Issue: 1, Pages: 3569
Published: Aug 8, 2019
Abstract
Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate the T cell receptor (TCR) repertoire by next-generation sequencing. A public αβTCR is identified from the cytotoxic T lymphocytes of patients with carbamazepine-SJS/TEN, with its expression showing drug/phenotype-specificity...
Paper Fields
Paper Details
Title
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Published Date
Aug 8, 2019
Volume
10
Issue
1
Pages
3569
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.