Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro
Abstract
Objectives Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin expression and whether tauroursodeoxycholic acid (TUDCA) is able to counteract such an anomaly. Methods Labial salivary glands from 16 SS patients and 15 control subjects, as well as 3D acini or...
Paper Details
Title
Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro
Published Date
Aug 3, 2019
Journal
Volume
59
Issue
4
Pages
742 - 753
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