Safety of nivolumab in metastatic renal cell carcinoma patients: A real-life experience in a Spanish urology setting.

Published on May 13, 2019in Actas Urologicas Espanolas0.994
· DOI :10.1016/J.ACUROE.2019.03.010
J. Amores Bermúdez2
Estimated H-index: 2
I. Osman García3
Estimated H-index: 3
+ 7 AuthorsA. Juárez Soto3
Estimated H-index: 3
Abstract Introduction and objectives Nivolumab is an immunotherapy agent that has been an approved treatment for previously treated patients with advanced renal cell carcinoma (RCC). Experience in real-life settings, especially regarding immune-related adverse events, is scarce. We present our experience with reference to the safety of nivolumab in patients with metastatic RCC (mRCC) treated in 9 hospitals in Spain. Material and methods Retrospective, multicenter study of patients with mRCC treated with nivolumab between 2016 and 2018. Data on baseline socio-demographic and clinical characteristics and drug-related adverse events were collected. Results The mean age of the 26 patients included was 63.7 ± 11.5 years; 96% were ECOG 0–1 and 78% had favorable or intermediate MSKCC risk scores; 73% had the clear cell histological subtype and 30% metastatic disease. Median follow-up was 9 months (range 1–14). All patients experienced an adverse event at different grades, with fatigue, fever and anemia being the most common (27%). Grade 3 adverse events occurred in 23% of patients. Adverse reactions led to treatment suspension in 3 patients (11%). Conclusion In the real-life clinical setting, nivolumab shows favorable outcomes, similar to those reported by other studies.
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