Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth
Abstract
Regulated growth plate activity is essential for postnatal bone development and body stature, yet the systems regulating epiphyseal fusion are poorly understood. Here, we show that the tissue inhibitors of metalloprotease (TIMP) gene family is essential for normal bone growth after birth. Whole-body quadruple-knockout mice lacking all four TIMPs have growth plate closure in long bones, precipitating limb shortening, epiphyseal distortion, and...
Paper Details
Title
Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth
Published Date
Aug 1, 2019
Journal
Volume
218
Issue
9
Pages
3134 - 3152
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