Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome
Abstract
Bicuspid aortic valve (BAV) disease is recognized to be a syndrome with a complex and multifaceted pathophysiology. Its progression is modulated by diverse evolutionary conserved pathways, such as Notch-1 pathway. Emerging evidence is also highlighting the key role of TLR4 signaling pathway in the aortic valve pathologies and their related complications, such as sporadic ascending aorta aneurysms (AAA). Consistent with these observations, we...
Paper Details
Title
Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome
Published Date
Jul 30, 2019
Journal
Volume
9
Issue
1
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